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Thinking and practice of accelerating transformation of traditional Chinese medicine from experiencemedicine to evidence-based medicine

Baoyan Liu, Yanhong Zhang, Jingqing Hu, Liyun He, Xuezhong Zhou

《医学前沿（英文）》 2011年第5卷第2期页码 163-170 doi: 10.1007/s11684-011-0143-9

摘要： The gradual development of Chinese medicine is based on constant accumulation and summary of experience in clinical practice, but without the benefit of undergoing the experimental medicine stage. Although Chinese medicine has formed a systematic and unique theory system through thousands of years, with the development of evidence-based medicine, the bondage of the research methods of experience medicine to Chinese medicine is appearing. The rapid transition and transformation from experience medicine to evidence-based medicine have become important content in the development of Chinese medicine. According to the features of Chinese medicine, we propose the research idea of “taking two ways simultaneously,” which is the study both in the ideal condition and in the real world. Analyzing and constructing the theoretical basis and methodology of clinical research in the real world, and building the stage for research technique is key to the effective clinical research of Chinese medicine. Only by gradually maturing and completing the clinical research methods of the real world could we realize “taking two ways simultaneously” and complementing each other, continuously produce scientific and reliable evidence of Chinese medicine, as well as transform and develop Chinese medicine from experience medicine to evidence-based medicine.

关键词： Chinese medicine experience medicine evidence-based medicine real world

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Experience inheritance from famous specialists based on real-world clinical research paradigm of traditionalChinese medicine

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《医学前沿（英文）》 2014年第8卷第3期页码 300-309 doi: 10.1007/s11684-014-0357-8

摘要：

The current modes of experience inheritance from famous specialists in traditional Chinese medicine (TCM) include master and disciple, literature review, clinical-epidemiology-based clinical research observation, and analysis and data mining via computer and database technologies. Each mode has its advantages and disadvantages. However, a scientific and instructive experience inheritance mode has not been developed. The advent of the big data era as well as the formation and practice accumulation of the TCM clinical research paradigm in the real world have provided new perspectives, techniques, and methods for inheriting experience from famous TCM specialists. Through continuous exploration and practice, the research group proposes the innovation research mode based on the real-world TCM clinical research paradigm, which involves the inheritance and innovation of the existing modes. This mode is formulated in line with its own development regularity of TCM and is expected to become the main mode of experience inheritance in the clinical field.

关键词： traditional Chinese medicine (TCM) real world clinical research paradigm famous specialist experience inheritance

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Aneurysmal dilatation of the aortic sinuses of Valsalva — beyond Marfan syndrome: a single centre experience

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《医学前沿（英文）》 2014年第8卷第4期页码 419-426 doi: 10.1007/s11684-014-0383-6

摘要：

Aneurysmal dilatation of the aortic sinuses of Valsalva has been most extensively documented in the setting of aortopathies, particularly Marfan syndrome. On the other hand, there is limited data in the literature about congenital sinus of Valsalva aneurysms outside this context. For the purpose of this review, we carried out a literature search on aneurysmal dilatation of the sinuses of Valsalva in Marfan syndrome, and compared this with congenital sinus of Valsalva aneurysms, also including data from a case series from our institution. In conclusion, there are differences in management of aortic dilatation in Marfan syndrome and congenital sinus of Valsalva aneurysms. Though less well-recognised, congenital aneurysms are often associated with significant morbidity and mortality and timely intervention is necessary.

关键词： sinus of Valsalva aneurysms Marfan syndrome aortic dissection

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Taizhou’s COVID-19 prevention and control experience with telemedicine features

Cenyi Shao, Shijian Li, Feng Zhu, Dahai Zhao, Hui Shao, Haixiao Chen, Zhiruo Zhang

《医学前沿（英文）》 2020年第14卷第4期页码 506-510 doi: 10.1007/s11684-020-0811-8

摘要： The outbreak of coronavirus disease 2019 (COVID-19) has spread rapidly around the world. As of May 30, 2020, a total of 84 568 confirmed COVID-19 cases have been recorded in China, with a mortality rate of approximately 5.5%. Taizhou is a prefecture-level city in Zhejiang Province. A total of 146 cases were diagnosed in this epidemic, with a fatality rate of 0%. This condition is due to the establishment of an “Internet+” diagnosis and treatment model based on online medical application (APP), telemedicine, WeChat service, and consultation hotline in Taizhou. Taizhou led in opening the “COVID-19 Prevention and Treatment Special Line” in China, which is conducive to pre-hospital screening, suppressing social panic, and clinical support. Hospitals also carried out related online lectures and popularization of science. We summarize Taizhou’s COVID-19 prevention and control experience with telemedicine features, with a view to providing reference for the control of the epidemic at home and abroad.

关键词： COVID-19 telemedicine prevention experience

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Individualized medicine, health medicine, and constitutional theory in Chinese medicine

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《医学前沿（英文）》 2012年第6卷第1期页码 1-7 doi: 10.1007/s11684-012-0173-y

摘要：

The patterns of modern science and changes in the medical model can result in the transformation of the current state of individualized and health medicines into being the primary trend in medical development. Chinese and Western medical systems are dissimilar in terms of value orientations, thinking style, and research directions because of their different historical and cultural backgrounds. Individualized treatment in modern medicine is mainly established based on individual genome information and the differences in mononucleotide polymorphi-sms. However, such treatment method is expensive, creates an uncertain genetic marker, and leads to different result interpretations, among other problems. The Chinese constitutional theory developed in the 1970s expresses the principle behind Chinese health medicine and individual treatment and provides the corresponding methods. The Chinese constitutional theory divides the constitution of the Chinese population into nine categories based on established classification criteria. It promotes the study of the relationship of each constitution to diseases and Chinese medicine preparation toward adjusting the constitution and preventing diseases. The theory also provides methods and tools for individualized treatment. Constitution identification shows the direction and provides the core technology for the evaluation of the health status. By combining the developments in modern biotechnology, new diagnostic techniques and treatment models of constitution-differentiation, disease-differentiation, and syndrome-differentiation can be established for the development of individualized Chinese medicine treatment and health medicine for the international medical community.

关键词： individualized medicine health medicine constitutional theory in Chinese medicine

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Clinical research of traditional Chinese medicine in big data era

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《医学前沿（英文）》 2014年第8卷第3期页码 321-327 doi: 10.1007/s11684-014-0370-y

摘要：

With the advent of big data era, our thinking, technology and methodology are being transformed. Data-intensive scientific discovery based on big data, named “The Fourth Paradigm,” has become a new paradigm of scientific research. Along with the development and application of the Internet information technology in the field of healthcare, individual health records, clinical data of diagnosis and treatment, and genomic data have been accumulated dramatically, which generates big data in medical field for clinical research and assessment. With the support of big data, the defects and weakness may be overcome in the methodology of the conventional clinical evaluation based on sampling. Our research target shifts from the “causality inference” to “correlativity analysis.” This not only facilitates the evaluation of individualized treatment, disease prediction, prevention and prognosis, but also is suitable for the practice of preventive healthcare and symptom pattern differentiation for treatment in terms of traditional Chinese medicine (TCM), and for the post-marketing evaluation of Chinese patent medicines. To conduct clinical studies involved in big data in TCM domain, top level design is needed and should be performed orderly. The fundamental construction and innovation studies should be strengthened in the sections of data platform creation, data analysis technology and big-data professionals fostering and training.

关键词： big data traditional Chinese medicine clinical evaluation evidence based medicine

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Knowledge-based competitive strategy using direct customer experience for automobile product development

Peter HODGES, Shuh Yuan LIOU,

《机械工程前沿（英文）》 2010年第5卷第1期页码 33-46 doi: 10.1007/s11465-009-0080-3

摘要： The automobile product development (PD) design space continually increases in size and complexity. In this dynamic environment, firms must identify competitive strategies that maintain or increase financial return. Firms can compete on several factors including price/cost, time-to-market, or differentiation (e.g., function or quality). Here, we envision that differentiation through expertise in integration can be a successful strategy in the automotive industry. Expertise in integration requires attention to knowledge management, which is crucial for competitive advantage []. A key component of the PD process is the acquisition of data about customers’ responses to vehicle performance and the rapid use of that information in the development of new products. The paper proposes a system for collecting near real-time data about responses to vehicle performance and its integration with recent developments in design and analysis. The proposed system would collect customer psychophysical response data, correlate it with vehicle parameter response data, and apply this information with feasible design automation to provide reduced cycle time, improved quality, and greater customer satisfaction. The paper discusses some relevant technological and legal constraints and concludes that such a system is feasible, can provide a near-term competitive advantage, and in the long-term, in some form, will be necessary for success.

关键词： product development strategy knowledge management

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Perioperative management for parturients with pulmonary hypertension: experience with 30 consecutive

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《医学前沿（英文）》 2013年第7卷第3期页码 395-395 doi: 10.1007/s11684-013-0289-8

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光照世界史坛的中医起源之谜

符友丰

《中国工程科学》 2006年第8卷第9期页码 1-12

摘要：

以疫病流行及其原型分析为线索，联系早期治法（如热熨、火灸、砭刺等）探讨了古代以腺鼠疫为代表的疫病流行与医学起源间的内在联系；以医源于疫的视野分析我国医史病史研究在出土文物、古文字和医学文献等方面丰富的信息资源与优势；分析解读疾病名实的古今变迁、比较中西医学及其在认识论与方法论上的差异，为审视我国传统医学在疫病防治方面的丰富经验与延至今日的独到成就与意义，疾病史研究成果与推广，实现古为今用，将为当今疫病防治的中西互补、中西医结合与比较提供宝贵的历史经验与借鉴。

关键词：世界医学史中医史医学起源鼠疫霍乱天花比较医学

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Practices, challenges, and opportunities: HIV/AIDS treatment with traditional Chinese medicine in China

Jian Wang, Wen Zou

《医学前沿（英文）》 2011年第5卷第2期页码 123-126 doi: 10.1007/s11684-011-0124-z

摘要： Traditional Chinese medicine (TCM) has become widely used in the treatment of acquired immune deficiency syndrome (AIDS) in China in recent years. In this article, we summarize the recent major developments in human immunodeficiency virus/AIDS (HIV/AIDS) treatment with TCM. The use of TCM is associated with preventing or alleviating HIV-related symptoms, reducing treatment side effects, and improving the quality of life. The potential beneficial effects of TCM should be confirmed through extensive and rigorous trials.

关键词： HIV/AIDS traditional Chinese medicine

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A stepwise process for carbon dioxide sequestration using magnesium silicates

Johan FAGERLUND, Experience NDUAGU, Ron ZEVENHOVEN, Inês ROMÃO,

《化学科学与工程前沿（英文）》 2010年第4卷第2期页码 133-141 doi: 10.1007/s11705-009-0259-5

摘要： This work involves the production of magnesium in the form of Mg(OH) from serpentinite rock (nickel mine tailing) material followed by conversion into MgCO using a pressurised fluidised bed (PFB) reactor operating at 400°C–600°C and pressures up to 2.85MPa. Our approach is rooted in the thermodynamic fact that the reaction between Mg(OH) and gaseous CO forming MgCO and water releases significant amounts of heat. The main problem is, however, the chemical kinetics; the reaction is slow and has to be accelerated in order to be used in an economically viable process for large-scale (~1Mt/a) CO sequestration. We have constructed a lab-scale PFB reactor test-setup for optimising the carbonation reaction. At high enough temperatures and conversion levels the reaction should provide the heat for the proceeding Mg(OH) production step, making the overall process energy neutral. So far we have been able to achieve a conversion degree of 26% at 500°C and 2.85MPa after 30min (particle size 125–212μm). In this paper the test facility and our latest results and progress on CO mineral carbonation are summarised. Also, the possible integration of the iron as a feedstock for iron and steel production will be briefly addressed. An interesting side-effect of this carbon dioxide capture and storage (CCS) route is that significant amounts of iron are obtained from the serpentinite rock material. This is released during the Mg(OH) production and can be of great interest to the iron- and steel producing sector, which at the same time is Finland’s largest CO producer.

关键词： carbonation reaction reactor producer large-scale process

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Traditional Chinese medicine in the new century

Jianxiang Liu, Zhu Chen

《医学前沿（英文）》 2011年第5卷第2期页码 111-114 doi: 10.1007/s11684-011-0125-y

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Do not let precision medicine be kidnapped

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《医学前沿（英文）》 2015年第9卷第4期页码 512-513 doi: 10.1007/s11684-015-0425-8

摘要：

Obama’s precision medicine initiative made the medical community boil over after the initiative’s release. Precision medicine has been advocated by the majority of scientists and doctors. However, some experts have questioned this concept. This article does not oppose precision medicine. However, the incentive of vigorously promoting precision medicine at present is a concern.

关键词： precision medicine personalized medicine genomics

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Practice and Experience of Canton Tower Project Management

Rong-hua Yi

《工程管理前沿（英文）》 2016年第3卷第1期页码 74-79 doi: 10.15302/J-FEM-2016013

摘要： This paper presents a brief introduction about the preliminary consulting and tender agent of Canton Tower, the basic situation of the whole-process supervision on the construction site, and a general summary of the Canton Tower project management. What’s more, the author suggests that some guidelines be formed for supervision enterprises involved in large-scale project management.

关键词： Canton Tower consultation tender agent whole-process supervision

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Holistic integrative medicine: toward a new era of medical advancement

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《医学前沿（英文）》 2017年第11卷第1期页码 152-159 doi: 10.1007/s11684-017-0499-6

摘要：

Medicine has encountered unprecedented problems associated with changes in nature, society, and environment, as well as with new human quests for survival, longevity, and health. In the meantime, the development of medicine is facing challenges that resulted from the over-division and specialization of disciplines and the fragmentation of medical knowledge. To construct a new medical system that is more suitable for human health and disease treatment, holistic integrative medicine (HIM), which regards the human body as a holistic entity, organically integrates the most advanced knowledge and theories in each medical field and the most effective practices in various clinical specialties to revise and adjust on the basis of social, environmental, and psychological conditions. HIM is the inevitable and necessary direction for the future development of medicine. In this article, we illustrated the connotation of HIM, the differences between HIM and other medical conceptions, and the practice of HIM in recent years.

关键词： holistic integrative medicine precision medicine general practice medicine